RESEARCH LINES

Biomaterials for Bone Regeneration and Immune Modulation

This research line centers on the development of advanced biomaterials to support bone regeneration in degenerative conditions such as osteoporosis and fragility fractures. The core strategy involves designing biomimetic nanoparticles capable of delivering therapeutic agents directly to bone cells, enhancing regeneration while reducing tissue degradation.

A key innovation lies in the integration of immune system modulation, where specific pathways are targeted to create a favorable environment for tissue repair and stem cell differentiation. These insights are applied to the creation of personalized 3D-printed scaffolds, which mimic the structure and composition of native bone and enable controlled release of bioactive compounds.

By combining nanotechnology, immunomodulation, and biofabrication, this research aims to establish next-generation biomaterials that offer precise, effective, and personalized solutions for bone tissue engineering.

Related funded projects
  • Title Biological tools for controlling the systemic and intracellular distribution of lipid-polymeric nanoparticles (BioNanoGene)
  • Amount granted EUR 98,000
  • Duration 36 months
  • Call Spanish Ministry of Science, Innovation and Universities – Generación de Conocimiento

  • Title Biomaterials for tissue engineering
  • Amount granted EUR 50,000
  • Duration 24 months
  • Call Xunta de Galicia – Oportunius

  • Title Networked Biofabrication Institute for Healthy Ageing (IBEROS+)
  • Amount granted EUR 250,000
  • Duration 24 months
  • Call European Comission – Interreg España-Portugal

Biomaterials and Drug Delivery Systems for Osteoarthritis Treatment

This research line is dedicated to the design and optimization of advanced biomaterials for the treatment of osteoarthritis (OA), a degenerative joint disease affecting millions worldwide. The focus is on developing intra-articular drug delivery systems (DDS) and scaffolds that not only relieve symptoms but also target the underlying mechanisms of joint degeneration.

By combining biomaterials, regenerative medicine, and artificial intelligence, we aim to create precision-engineered DDS capable of sustained drug release and enhanced therapeutic efficacy. These systems include nanostructured lipid carriers, microparticles, scaffolds and hydrogels, designed to deliver anti-inflammatory and regenerative agents directly to affected joints.

A key innovation in this research is the use of AI-assisted formulation design, which enables efficient optimization of DDS properties and fabrication processes. This approach supports the development of disease-modifying OA therapies (DMOADs) that can slow or halt disease progression, offering long-term benefits for patients.

Through the integration of smart biomaterials and computational tools, this research line aims to advance OA treatment beyond symptom management, paving the way for personalized and effective osteochondral regeneration strategies.

Related funded projects
  • Title Development of an Innovative Targeted Therapy for Osteoarthritis (TARGET-OA)
  • Amount granted EUR 607,000
  • Duration 18 months
  • Call IGNICIA Proof of Concept Program

  • Title Development of a Disease-Modifying Therapy for Precision Medicine in Knee Osteoarthritis
  • Amount granted EUR 137,000
  • Duration 24 months
  • Call Carlos III Health Institute, Spanish Ministry of Science, Innovation and Universities – Desarrollo Tecnológico en Salud

Bioactive Biomaterials using Natural Extracts for Animal Health

This research line focuses on the development of bioactive biomaterials derived from natural plant extracts to provide antimicrobial and antioxidant protection in livestock. These materials are designed to support animal health in species such as cattle, pigs and fish, offering an effective alternative to conventional antibiotics.

By incorporating compounds like polyphenols, naturally occurring plant defenses, into innovative delivery systems, the research aims to reduce the emergence of antimicrobial resistance while enhancing immune resilience. A key feature of this approach is the valorization of agricultural byproducts contributing to sustainable and circular bioeconomy practices.

The integration of biomaterials science, veterinary medicine, and green technologies enables the creation of targeted, eco-friendly solutions that promote animal welfare and environmental sustainability.

Related funded projects
  • Title The power of grape extracts: antimicrobial and antioxidant properties to prevent the use of antibiotics in farmed animals (NeoGiANT)
  • Amount granted EUR 9,330,000
  • Duration 48 months
  • Call European Comission – H2020-LC-GD-2020

Funding